KwaZulu-Natal HIV

DRUG  RESISTANCE  SURVEILLANCE  STUDY

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ART Need and Coverage



VF AND HIV DRUG RESISTANCE: NO SMALL PROBLEM



Key Clinical / Programmatic Questions


34 million people living with HIV
23.5 M (2/3) in SSA
5.6 M (16%) in SA
16.7 million people need ART*
11 M in SSA
2.5 M in SA
9.7 million people receiving ART
7.5 M in SSA (68%)
2.1 M in SA (84%)

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Worldwide estimates of 3-30% virologic failure within one year of first ART (500K – 5M)*
40-95% individuals VF have > 1 major resistance mutation
1.2-25.5% of individuals on ART will have drug resistance within one year (200K – 4.3M)*
Over time triple class failure will accumulate

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Can we predict which patients are likely to experience virologic failure?
Before starting
While on treatment
Can we prevent these patients from experiencing virologic failure?

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